4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methoxy-pyrimidin-2-one

Names

[ Name ]:
4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methoxy-pyrimidin-2-one

[Synonym ]:
5-methoxy-cytidine
5-Methoxycytidin

Biological Activity

[Description]:

5-Methoxy cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

Chemical & Physical Properties

[ Density]:
1.81g/cm3

[ Boiling Point ]:
569.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅N₃O₆

[ Molecular Weight ]:
273.24

[ Flash Point ]:
298.4ºC

[ Exact Mass ]:
273.09600

[ PSA ]:
140.06000

[ Index of Refraction ]:
1.706

[ Storage condition ]:
2-8°C

Related Compounds

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