Sulfamethomidine

Names

[ Name ]:
Sulfamethomidine

[Synonym ]:
Methofazine
N1-<6-Methoxy-2-methyl-pyrimidinyl-(4)>-sulfanilamid
4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)-benzenesulfonamide
Duroprocin
Sulfametomidina [INN-Spanish]
Sulfamethomidine
Sulfametomidine
Methofadin
Sulfanilsaeure-(6-methoxy-2-methyl-pyrimidin-4-ylamid)
sulfanilic acid-(6-methoxy-2-methyl-pyrimidin-4-ylamide)
SA 412
EINECS 223-219-5
Sulfametomidinum [INN-Latin]
Solfametomidina [DCIT]
4-<4-Amino-benzolsulfonylamino>-6-methoxy-2-methyl-pyrimidin
Sulfamethomidin

Biological Activity

[Description]:

Sulfamethomidine is an antibacterial agent[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. TRUANT JP, et al. ENHANCEMENT OF INHIBITORY EFFECT AGAINST GRAM-NEGATIVE ORGANISMS WITH COLISTIN SULFATE AND CERTAIN SULFONAMIDES. Antimicrob Agents Chemother (Bethesda). 1963;161:420-426.

Chemical & Physical Properties

[ Density]:
1.418g/cm3

[ Boiling Point ]:
501.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₄N₄O₃S

[ Molecular Weight ]:
294.33000

[ Flash Point ]:
257.2ºC

[ Exact Mass ]:
294.07900

[ PSA ]:
115.58000

[ LogP ]:
2.91160

[ Index of Refraction ]:
1.633

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0110000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(6-methoxy-2-methyl-4-pyrimidinyl)-

CAS REGISTRY NUMBER :: 3772-76-7

BEILSTEIN REFERENCE NO. :: 0284949

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H14-N4-O3-S

MOLECULAR WEIGHT :: 294.36

WISWESSER LINE NOTATION :: T6N CNJ B1 DO1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,17,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,17,1973

Safety Information

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%