Maraviroc
Names
[ CAS No. ]:
376348-65-1
[ Name ]:
Maraviroc
[Synonym ]:
4,4-Difluoro-N-{(1S)-3-[(1R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
Maraviroc
4,4-difluoro-N-[(1S)-3-{(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide
exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide
maroviroc
Celsentri
Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-
Cyclohexanecarboxamide, 4,4-difluoro-N-((1S)-3-((3-exo)-3-(3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)-
Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-
Biological Activity
[Description]:
[Related Catalog]:
[Target]
MIP-1α-CCR5:3.3 nM (IC50, in HEK-293 cell membrane)
RANTES-CCR5:5.2 nM (IC50, in HEK-293 cell membrane)
MIP-1β-CCR5:7.2 nM (IC50, in HEK-293 cell membrane)
HIV-1 (Ba-L):1.1 nM (IC50, in PM-1 cells)
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Melting Point ]:
79-81ºC
[ Molecular Formula ]:
C29H41F2N5O
[ Molecular Weight ]:
513.666
[ Exact Mass ]:
513.327942
[ PSA ]:
63.05000
[ LogP ]:
3.60
[ Index of Refraction ]:
1.628
[ Storage condition ]:
Store at +4°C
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
48/22
[ Safety Phrases ]:
22-36
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2934999090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Eur. J. Immunol. 45(1) , 101-12, (2015)
Serum amyloid A (SAA) is an acute phase protein that is upregulated in inflammatory diseases and chemoattracts monocytes, lymphocytes, and granulocytes via its G protein-coupled receptor formyl peptid...
Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes.J. Thromb. Haemost. 13 , 1676-82, (2015)
We aimed to evaluate the mechanisms underlying the effects of red blood cells (RBCs) on the reactivity of monocytes to lipopolysaccharide (LPS) stimulation.Measurements of tissue factor (TF) antigen a...
Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.Antimicrob. Agents Chemother. 59(1) , 397-406, (2014)
GSK1265744 is a new HIV integrase strand transfer inhibitor (INSTI) engineered to deliver efficient antiviral activity with a once-daily, low-milligram dose that does not require a pharmacokinetic boo...