2-Clorocinnamic acid

Names

[ Name ]:
2-Clorocinnamic acid

[Synonym ]:
2-Chloro cinnamic acid
EINECS 223-154-2
o-chloro-cinnamicaci
Chlorocinnamicacid
(2E)-3-(2-chlorophenyl)prop-2-enoic acid
O-CHLOROCINNAMIC ACID
2-ChlorocinnaMic Acid
(2E)-3-(2-Chlorophenyl)acrylic acid
MFCD00004372
2-Clorocinnamic acid
2-Propenoic acid, 3-(2-chlorophenyl)-, (2E)-
RARECHEM BK HC T319
3-(2-Chlorophenyl)acrylic acid

Biological Activity

[Description]:

2-Chlorocinnamic acid is a kind of trans-cinnamate[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
321.6±17.0 °C at 760 mmHg

[ Melting Point ]:
208-210 °C(lit.)

[ Molecular Formula ]:
C₉H₇ClO₂

[ Molecular Weight ]:
182.60

[ Flash Point ]:
148.3±20.9 °C

[ Exact Mass ]:
182.013458

[ PSA ]:
37.30000

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.628

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD8450000

CHEMICAL NAME :: Cinnamic acid, o-chloro-

CAS REGISTRY NUMBER :: 3752-25-8

BEILSTEIN REFERENCE NO. :: 1365198

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-Cl-O2

MOLECULAR WEIGHT :: 182.61

WISWESSER LINE NOTATION :: QV1U1R BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 989 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 23,714,1968

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >350 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - rigidity (including catalepsy)

REFERENCE :: IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,77,1987

Safety Information

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36

[ WGK Germany ]:
3

[ RTECS ]:
GD8450000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%