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Kisspeptin-54 (human) trifluoroacetate salt

Names

[ CAS No. ]:
374683-24-6

[ Name ]:
Kisspeptin-54 (human) trifluoroacetate salt

Biological Activity

[Description]:

Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) hinders tumor metastasis and stimulates gonadotropin secretion[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor
Research Areas >> Cancer
Research Areas >> Endocrinology

[Target]

Ki: 1.81 nM (Rat GPR54) and 1.45 nM (Human GPR54)[2]


[References]

[1]. M L Gottsch, et al. A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse. Endocrinology. 2004 Sep;145(9):4073-7.

[2]. M Kotani, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C258H401N79O78

Related Compounds