MitoBloCK 1

Names

[ Name ]:
MitoBloCK 1

[Synonym ]:
Hydrazinecarbothioamide, 2-[(3-bromo-6,7,8,9-tetrahydro-2-hydroxy-1-dibenzofuranyl)methylene]-, (2E)-
(2E)-2-[(3-Bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene]hydrazinecarbothioamide

Biological Activity

[Description]:

MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways; also inhibits growth of mammalian cells and import of the ADP/ATP carrier, but not TIM23 substrates; an useful chemical tool for investigation mammalian mitochondrial import and dysfunction linked to inherited human disease.

[References]

References 1. Hasson SA, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9578-83. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
513.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₄BrN₃O₂S

[ Molecular Weight ]:
368.249

[ Flash Point ]:
264.1±32.9 °C

[ Exact Mass ]:
366.998993

[ LogP ]:
5.15

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.769

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.