1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Names

[ Name ]:
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

[Synonym ]:
1,6-DIHYDRO-1-METHYL-6-OXOPYRIDINE-3-CARBOXYLIC ACID
1-methyl-6-oxopyridine-3-carboxylic acid
Nudifloric acid
1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid

Biological Activity

[Description]:

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Suh W, et al. Chemical Constituents Identified from Fruit Body of Cordyceps bassiana and Their Anti-Inflammatory Activity. Biomol Ther (Seoul). 2017 Mar 1;25(2):165-170.

Chemical & Physical Properties

[ Density]:
1.381g/cm3

[ Boiling Point ]:
329.6ºC at 760mmHg

[ Molecular Formula ]:
C₇H₇NO₃

[ Molecular Weight ]:
153.13500

[ Flash Point ]:
153.2ºC

[ Exact Mass ]:
153.04300

[ PSA ]:
59.30000

[ LogP ]:
0.08350

[ Index of Refraction ]:
1.577

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Identification of N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-5-carboxamide as components in urine extracts of individuals consuming coffee.

J. Pharm. Biomed. Anal. 30(3) , 773-80, (2002)

Caffeine metabolites were extracted from urine samples collected 4 h after consumption of a cup of coffee and were separated by high-performance liquid chromatography (HPLC) on a C18 (5 microm) revers...

Urinary excretion of N1-methyl-2-pyridone-5-carboxylic acid and the fate of remaining of trigonelline.

Adv. Exp. Med. Biol. 398 , 599-603, (1996)

Nicotinamide and insulin sensitivity.

Diabetologia 36(4) , 369, (1993)