Z-Leu-Leu-Leu-fluoromethyl ketone

Names

[ CAS No. ]:
371167-61-2

[ Name ]:
Z-Leu-Leu-Leu-fluoromethyl ketone

Biological Activity

[Description]:

Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

cysteine protease[1].


[References]

[1]. Simmons G, et al. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81.  

[2]. Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H42FN3O5

[ Molecular Weight ]:
507.64

Related Compounds

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