371167-61-2

371167-61-2 structure

Name: Z-Leu-Leu-Leu-fluoromethyl ketone
Chemical Name: Z-Leu-Leu-Leu-fluoromethyl ketone
CAS Number: 371167-61-2
Molecular Formula: C₂₇H₄₂FN₃O₅
Molecular Weight: 507.64
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-12-21 18:08:36
Modify Date: 2025-10-04 13:17:48
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge[1][2].

Name	Z-Leu-Leu-Leu-fluoromethyl ketone

Description	Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	cysteine protease[1].
References	[1]. Simmons G, et al. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81. [2]. Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8.

Molecular Formula	C₂₇H₄₂FN₃O₅
Molecular Weight	507.64