ROS kinases-IN-1

Names

[ Name ]:
ROS kinases-IN-1

Biological Activity

[Description]:

ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

[Target]

IC50: 1.22 μM (ROS kinase)[1]

[In Vitro]

ROS kinases-IN-1 (1-100 μM; 1 d) inhibits the growth of cervical cancer cell and glioblastoma cells[1]. Cell Viability Assay[1] Cell Line: HeLa, U138, U87, LN18, and U118 cells Concentration: 1, 10, and 100 μM Incubation Time: one day Result: Showed EC50s for HeLa, U138, U87, LN18, and U118 cells of 20, 8, 8, 12, and 7 μM, respectively.

[References]

[1]. Dorre A. GRUENEBERG, et al. Novel methods, compounds, and compositions for inhibition of ros. WO2014141129A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₆N₄O

[ Molecular Weight ]:
328.373

Related Compounds

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