5,10,15,20-Tetrakis(N-methyl-4-pyridyl)porphine tetratosylate

Names

[ Name ]:
5,10,15,20-Tetrakis(N-methyl-4-pyridyl)porphine tetratosylate

[Synonym ]:
4,4',4'',4'''-(5,10,15,20-Porphyrintetrayl)tetrakis(1-methylpyridinium) tetrakis(4-methylbenzenesulfonate)
TMPyP4 tosylate
4-methylbenzenesulfonate,5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,22-dihydroporphyrin
4,4',4'',4'''-Porphyrin-5,10,15,20-tetrayltetrakis(1-methylpyridinium) tetrakis(4-methylbenzenesulfonate)
5,10,15,20-Tetrakis(N-methyl-4-pyridyl)porphine tetratosylate
MFCD00013468
TMPyP ,Mg] [Fo
α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate
TMPYP
tmpyp tetratosylate

Biological Activity

[Description]:

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand, which inhibits the interaction between G-quadruplexes and IGF-1[1]. TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> G-quadruplex

Signaling Pathways >> Cell Cycle/DNA Damage >> Telomerase

[Target]

G-quadruplex[2] Telomerase[2]

[References]

[1]. Chen H, et al. Insulin-like growth factor type I selectively binds to G-quadruplex structures. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):31-38.

[2]. Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₂H₆₆N₈O₁₂S₄

[ Molecular Weight ]:
1363.60

[ Exact Mass ]:
1362.368286

[ PSA ]:
334.14000

[ LogP ]:
10.08380

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
water: soluble50MM(lit.)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Articles

Platinum nanoparticles on porphyrin functionalized graphene nanosheets as a superior catalyst for methanol electrooxidation.

Nanoscale 6(24) , 14999-15007, (2014)

A novel nanostructured catalyst of platinum nanoparticles supported on 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) (TMPyP) functionalized graphene (TMPyP-graphene) is ...

"Turn-off-on" fluorescent sensor for (N-methyl-4-pyridyl) porphyrin -DNA and G-quadruplex interactions based on ZnCdSe quantum dots.

Anal. Chim. Acta 888 , 131-7, (2015)

As a new detection model, the reversible fluorescence "turn-off-on" sensor based on quantum dots (QDs) has already been successfully employed in the detections of many biochemical materials, especiall...

The singlet-oxygen-sensitized delayed fluorescence in mammalian cells: a time-resolved microscopy approach.

Photochem. Photobiol. Sci. 14(4) , 700-13, (2015)

The present work provides a proof-of-concept that the singlet oxygen-sensitized delayed fluorescence (SOSDF) can be detected from individual living mammalian cells in a time-resolved microscopy experi...

Related Compounds

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