Isorhamnetin 3-glucuronide

Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Isorhamnetin 3-glucuronide (0-100 µM; 48 h) 以剂量依赖的方式对 MCF-7 细胞显示出抗增殖活性[1]。 Isorhamnetin 3-glucuronide (0-100 µM; 48 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 S 期[1]。 Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 0, 25, 50, 100 µM Incubation Time: 48 h Result: Inhibited cell proliferation in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: MCF-7 cells Concentration: 25, 100 µM Incubation Time: 48 h Result: Induced apoptosis with the rate of 16.8%, 49.8% at 25, 100 µM, respectively. Cell Cycle Analysis[1] Cell Line: MCF-7 cells Concentration: 0, 50, 100 µM Incubation Time: 48 h Result: Induced cell cycle arrest at S-phase.

[1]. Wu Q, et al. Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. J Agric Food Chem. 2018 Jul 11;66(27):7181-7189.