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Isorhamnetin 3,7-O-diglucoside

Names

[ CAS No. ]:
6758-51-6

[ Name ]:
Isorhamnetin 3,7-O-diglucoside

[Synonym ]:
isorhamnetin-3,7-di-O-β-D-glucopyranoside
isorhamnetin 3,7-di-O-β-D-glucopyranoside
isorhamnetin 3,7-di-β-D-glucopyranoside
isorhamnetin-3,7-O-β-D-diglucopyranoside
3,7-di-O-β-D-glucopiranozyd izoramnetyny
isorhamnetin 3,7-O-di-β-D-glucopyranoside
Isorhamnetin 3,7-O-diglucoside

Biological Activity

[Description]:

Isorhamnetin 3,7-di-O-β-D-glucopyranoside, a major flavonoid compound, is metabolized in vivo by intestinal bacteria to isorhamnetin and that isorhamnetin plays an important role as an antioxidant[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vivo]

Isorhamnetin 3,7-di-O-β-D-glucopyranoside (10 or 20 mg/kg of body weight/day for 10 days; p.o.) to rats with streptozotocin-induced diabetes significantly reduced serum levels of glucose and 5-(hydroxymethyl)furfural (5-HMF), which is glycosylated with hemoglobin and is an indicator of oxidative stress[1]. Animal Model: Male Wistar rats (5 weeks old, 120-130 g) (STZ-induced diabetic rats had higher glucose and 5-HMF levels than normal rats)[1] Dosage: 10 or 20 mg/kg of body weight Administration: P.o.; daily for 10 days Result: The serum glucose levels of rats given 10 and 20 mg of orally were 510.1 and 492.4 mg/dL, respectively, whereas the control level was 574.2 mg/dL.

[References]

[1]. Yokozawa T, et al. Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. J Agric Food Chem. 2002;50(19):5490-5495.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H32O17

[ Molecular Weight ]:
640.54300

[ Exact Mass ]:
640.16400

[ PSA ]:
278.66000

[ Storage condition ]:
-20℃

Precursor & DownStream

Precursor

DownStream

Related Compounds