PGP 4008

Names

[ Name ]:
PGP 4008

Biological Activity

[Description]:

PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple drug resistance (MDR) solid tumor model when given in combination with Doxorubicin[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[References]

[1]. Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₃N₃O

[ Molecular Weight ]:
393.48000

[ Exact Mass ]:
393.18400

[ PSA ]:
48.72000

[ LogP ]:
5.69320

Related Compounds

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