propiomazine

Names

[ CAS No. ]:
362-29-8

[ Name ]:
propiomazine

[Synonym ]:
Propiomazinum
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
Propiomazinum [INN-Latin]
Propiomazina [INN-Spanish]
Wy-1359
Largon
Dorevan
Phenoctyl
1-[10-(2-dimethylamino-propyl)-10H-phenothiazin-2-yl]-propan-1-one
Propionylpromethazine
Propiomazina
1-[10-(2-dimethylamino-propyl)-phenothiazin-2-yl]-propan-1-one
10-<2-Dimethylamino-propyl>-3-propionyl-phenothiazin
3-Propionyl-10-<2-dimethylamino-propyl>-phenothiazin
1-[10-(2-Dimethylamino-propyl)-phenothiazin-2-yl]-propan-1-on

Biological Activity

[Description]:

Propiomazine is an orally active antihistamine agent with sedative effects. Propiomazine can be used in the research of insomnia[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vivo]

Propiomazine (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations[3]. Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl4-induced hepatic injury[4]. Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats[5].

Chemical & Physical Properties

[ Density]:
1.137g/cm3

[ Boiling Point ]:
500.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₄N₂OS

[ Molecular Weight ]:
340.48200

[ Flash Point ]:
256.7ºC

[ Exact Mass ]:
340.16100

[ PSA ]:
48.85000

[ LogP ]:
4.89710

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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