Kobusin

Names

[ Name ]:
Kobusin

[Synonym ]:
Kobusin

Biological Activity

[Description]:

Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vitro]

Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells[1].

[In Vivo]

In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice[1].

[References]

[1]. Yu Jiang , et al. Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci. 2015 Nov 25;6:1041.

[2]. Xing Zhang, et al. Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects. RSC Adv., 2017,7, 34236-34243.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₂O₆

[ Molecular Weight ]:
370.39600

[ Exact Mass ]:
370.14200

[ PSA ]:
55.38000

[ LogP ]:
3.50770

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.