Dehydroleucodine

Names

[ Name ]:
Dehydroleucodine

[Synonym ]:
DEHYDROACHILLIN
11,13-Dehydroleucodin Dehydroleucodin Leucodin Lidbeckialactone Mesatlantin E

Biological Activity

[Description]:

Dehydroleucodine is a sesquiterpene lactone isolated from Gynoxys verrucosa. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[References]

[1]. Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6.

[2]. Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803.

[3]. Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23.

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
450.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₁₆O₃

[ Molecular Weight ]:
244.28600

[ Flash Point ]:
203.1ºC

[ Exact Mass ]:
244.11000

[ PSA ]:
43.37000

[ LogP ]:
2.33970

[ Index of Refraction ]:
1.562

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana.

Fitoterapia 79(1) , 1-5, (2008)

Dehydroleucodine (DhL), a sesquiterpene lactone obtained from Artemisia douglasiana, was screened for antidiarrheal effects. DhL inhibited castor oil-induced diarrhea in mice by judged by a decrease i...

Role of mast cells in gastrointestinal mucosal defense.

Biocell 27(2) , 163-72, (2003)

The purpose of this review, based on studies from our laboratory as well as from others, is to summarize salient features of mast cell immunobiology and to describe their associations with gastrointes...

Effect of dehydroleucodine on intestinal transit: structural basis of the interaction with the α(2)-adrenergic receptor.

Eur. Biophys. J. 40(8) , 981-6, (2011)

The activity of dehydroleucodine, a sesquiterpene lactone obtained from Artemisia douglasiana, was studied in mice small intestinal transit. Its mechanism was evaluated in the presence of several adre...

Related Compounds

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