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Butriptyline

Names

[ CAS No. ]:
35941-65-2

[ Name ]:
Butriptyline

[Synonym ]:
ButriptylineHCl
Butriptylene hydrochloride
butripyline
5-(2-Methyl-3-Dimethylaminopropyl)Dibenzo<a,d>Cycloheptadien
Evadyne
Butriptylin*HCl

Biological Activity

[Description]:

Butriptyline (Butriptylene) is an orally active tricyclic antidepressant agent[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

Butriptyline (1000 mg/kg; in diet; 10 weeks) shows anti-obesity effect in mice[1]. Butriptyline hydrochloride (2.5-30 mg/kg; i.p.; 10-15 day intervals) causes a dose dependent depression of the food reinforced responses and slightly depresses the avoidance reflex at the highest doses in male albino rats[2]. Animal Model: Female CFLP mice, monosodium glutamate (MSG)-induced obesity model[1] Dosage: 1000 mg/kg Administration: In diet, 10 weeks Result: Significantly lowered the body weight.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H27N

[ Molecular Weight ]:
293.44600

[ Exact Mass ]:
293.21400

[ PSA ]:
3.24000

[ LogP ]:
4.50490

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HO8887000
CHEMICAL NAME :
5H-Dibenzo(a,d)cycloheptene-5-propanamine, 10-11-dihydro-N,N,beta-trimethyl-, (+-)-
CAS REGISTRY NUMBER :
35941-65-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H27-N
MOLECULAR WEIGHT :
293.49
WISWESSER LINE NOTATION :
L C676&T&J B1Y1&1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75 mg/kg
SEX/DURATION :
female 4-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JNMDBO Journal of Medicine (Westbury, NY). (PJD Pub., Ltd., POB 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 2,271,1971

Safety Information

[ RIDADR ]:
UN 1851

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2921499090

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

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