MELPERONE

Names

[ Name ]:
MELPERONE

[Synonym ]:
FLUBUPERONE
Metylperonum
Melperonum [INN-Latin]
Melperona [INN-Spanish]
1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)-1-butanone
Methylperone
Bunil
1-(4-fluoro-phenyl)-4-(4-methyl-piperidin-1-yl)-butan-1-one
4'-Fluoro-4-(4-methylpiperidino)butyrophenone
MELPERONE
Buronil

Biological Activity

[Description]:

Melperone, a butyrophenone, is an antipsychotic drug used for sleep induction which is frequently prescribed in psychiatric setting[1]. Melperone has been used for a variety of indications, including the treatment of schizophrenia, but also for agitation in the elderly[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Hefner G, et al. Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of CYP2D6: evidence from a therapeutic drug monitoring survey. J Neural Transm (Vienna). 2015 Nov;122(11):1609-17.

[2]. Bobo WV, et al. Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics. Hum Psychopharmacol. 2009 Jul;24(5):415-22.

Chemical & Physical Properties

[ Density]:
1.046g/cm3

[ Boiling Point ]:
376.1ºC at 760mmHg

[ Melting Point ]:
78-82°C

[ Molecular Formula ]:
C₁₆H₂₂FNO

[ Molecular Weight ]:
263.35000

[ Flash Point ]:
181.3ºC

[ Exact Mass ]:
263.16900

[ PSA ]:
20.31000

[ LogP ]:
3.45840

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Precursor & DownStream

Precursor

DownStream

Related Compounds

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