BVFP

Names

[ CAS No. ]:
357158-20-4

[ Name ]:
BVFP

Biological Activity

[Description]:

BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor
Research Areas >> Neurological Disease

[References]

[1]. Lee WC, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23(6):1467-78.  

Chemical & Physical Properties

[ Molecular Formula ]:
C13H8BrF3N2O

[ Molecular Weight ]:
345.11

Related Compounds

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