Ethanol, 2-chloro-,1-methanesulfonate
Names
[ CAS No. ]:
3570-58-9
[ Name ]:
Ethanol, 2-chloro-,1-methanesulfonate
[Synonym ]:
2-Chloroethylmethanesulfonate
2-Chloroethyl Methanesulfonate
2-Chloroethyl methanesulphonate
Methanesulfonic acid,2-chloroethyl ester
2-chloroethyl mesylate
2-Chlorethylmesylat
EINECS 222-672-6
CB 1506
Chloroethyl methanesulfonate
2-Chloroethylmethanesulfonate,puriss
Methanesulfonic Acid 2-Chloroethyl Ester
MFCD00007560
Chloroethyl methanesulphonate
Chemical & Physical Properties
[ Density]:
1.39 g/mL at 25ºC(lit.)
[ Boiling Point ]:
125-126ºC9 mm Hg(lit.)
[ Melting Point ]:
6ºC
[ Molecular Formula ]:
C3H7ClO3S
[ Molecular Weight ]:
158.60400
[ Flash Point ]:
>230 °F
[ Exact Mass ]:
157.98000
[ PSA ]:
51.75000
[ LogP ]:
1.28220
[ Index of Refraction ]:
n20/D 1.456(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KK1960000
- CHEMICAL NAME :
- Ethanol, 2-chloro-, methanesulfonate
- CAS REGISTRY NUMBER :
- 3570-58-9
- BEILSTEIN REFERENCE NO. :
- 1754022
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C3-H7-Cl-O3-S
- MOLECULAR WEIGHT :
- 158.61
- WISWESSER LINE NOTATION :
- WS1&O2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 143 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Blood - leukopenia Blood - thrombocytopenia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 127 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Liver - other changes Tumorigenic - tumors at site of application
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 208 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 250 mg/kg
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- male 4 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Mold - Neurospora crassa
- DOSE/DURATION :
- 100 mmol/L
- REFERENCE :
- MGBUA3 Microbial Genetics Bulletin. (Ohio State Univ., College of Biological Science, Dept. of Microbiology, 484 W. 12th Ave., Columbus, OH 43210) No.1- 1950- Volume(issue)/page/year: 17,5,1960
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332-H351
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S23;S45;S36/S37/S39
[ RIDADR ]:
UN 2810 6
[ WGK Germany ]:
3
[ RTECS ]:
KK1960000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Mutat. Res. 331(2) , 213-24, (1995)
The 2-chloroethyl methanesulfonate (2ClEMS)-induced alcohol dehydrogenase (Adh) null germline mutation frequency in treated Drosophila melanogaster second instar larval gonia was two orders of magnitu...