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Dihydrobaicalein

Names

[ CAS No. ]:
35683-17-1

[ Name ]:
Dihydrobaicalein

[Synonym ]:
4H-1-Benzopyran-4-one, 2,3-dihydro-5,6,7-trihydroxy-2-phenyl-, (2S)-
(2S)-5,6,7-Trihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one

Biological Activity

[Description]:

Dihydrobaicalein is a PLK1 Inhibitor with an IC50 of 6.3 μM. Dihydrobaicalein also inhibits VRK2 and PLK2. Dihydrobaicalein is a natural product that can be isolated from Scutellaria scandens[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)

[Target]

PLK1


[References]

[1]. Woo SU, et al. 7-O-Methylwogonin from Scutellaria baicalensis Disturbs Mitotic Progression by Inhibiting Plk1 Activity in Hep3B Cells. Planta Med. 2019 Feb;85(3):217-224.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
595.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H12O5

[ Molecular Weight ]:
272.25

[ Flash Point ]:
231.7±23.6 °C

[ Exact Mass ]:
272.068481

[ LogP ]:
3.83

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.693

Related Compounds