5-methoxyuridine

Names

[ Name ]:
5-methoxyuridine

[Synonym ]:
5-OMe-uridine
5-METHOXYURIDINE

Biological Activity

[Description]:

5-Methoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.65±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₁₀H₁₄N₂O₇

[ Molecular Weight ]:
274.23

[ Exact Mass ]:
274.08000

[ PSA ]:
134.01000

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Codon recognition by tRNA molecules with a modified or unmodified uridine at the first position of the anticodon.

Nucleic Acids Symp. Ser. 34 , 203-204, (1995)

Effects of a single nucleoside modification at the first position of the anticodon of a transfer RNA molecule on its codon reading properties were investigated by use of a cell-free protein synthesis....

5-methoxyuridine: a new minor constituent located in the first position of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis.

Nucleic Acids Res. 3 , 2851-2860, (1976)

The sequences of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis W 168 were N-G-C, N-G-U, and N-A-C, respectively. A new minor constituent, N, occupied the first position of the ...

Bacillus subtilis tRNA(Pro) with the anticodon mo5UGG can recognize the codon CCC.

Biochim. Biophys. Acta 1728 , 143-149, (2005)

In Bacillus subtilis, four codons, CCU, CCC, CCA, and CCG, are used for proline. There exists, however, only one proline-specific tRNA having the anticodon mo(5)UGG. Here, we found that this tRNA(Pro)...

Related Compounds

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