(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE

Names

[ Name ]:
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE

[Synonym ]:
IN1462
HMS3229F13
HMS2043P17
IKK-2 Inhibitor VI

Biological Activity

[Description]:

IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Inflammation/Immunology

[Target]

IKK-2:25 nM (IC50)

[References]

[1]. Baxter A, et, al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₁N₃O₂S

[ Molecular Weight ]:
261.30

[ Exact Mass ]:
261.05700

[ PSA ]:
128.43000

[ LogP ]:
3.47560

Related Compounds

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