CID1231538

Names

[ Name ]:
CID1231538

[Synonym ]:
N-{2-[(4-Chlorobenzyl)sulfanyl]-1,3-benzothiazol-6-yl}-2-(4-morpholinylcarbonyl)benzamide
Benzamide, N-[2-[[(4-chlorophenyl)methyl]thio]-6-benzothiazolyl]-2-(4-morpholinylcarbonyl)-

Biological Activity

[Description]:

CID1231538, a benzothiazole analogue, is a potent GPR35 antagonist (IC50=0.55 μM). GPR35 is a G protein-coupled receptor (GPCR)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vitro]

GPR35 has gained special consideration as a result of its association with many diseases including type-2 diabetes, nociceptive pain, inflammation, mild mental retardation syndrome, metabolic disorders, and gastric cancer[1].

[References]

[1]. Abdalhameed MM, et al. Structure-activity relationships of benzothiazole GPR35 antagonists. Bioorg Med Chem Lett. 2017;27(3):612-615.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₆H₂₂ClN₃O₃S₂

[ Molecular Weight ]:
524.05

[ Exact Mass ]:
523.079102

[ LogP ]:
3.00

[ Index of Refraction ]:
1.725

Related Compounds

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