354126-20-8

354126-20-8 structure

Name: CID1231538
Chemical Name: N-{2-[(4-Chlorobenzyl)sulfanyl]-1,3-benzothiazol-6-yl}-2-(4-morpholinylcarbonyl)benzamide
CAS Number: 354126-20-8
Molecular Formula: C₂₆H₂₂ClN₃O₃S₂
Molecular Weight: 524.05
Catalog: Research Areas Inflammation/Immunology
Create Date: 2021-12-23 00:34:41
Modify Date: 2025-08-26 22:11:36
CID1231538, a benzothiazole analogue, is a potent GPR35 antagonist (IC50=0.55 μM). GPR35 is a G protein-coupled receptor (GPCR)[1].

Name	N-{2-[(4-Chlorobenzyl)sulfanyl]-1,3-benzothiazol-6-yl}-2-(4-morpholinylcarbonyl)benzamide
Synonyms	N-{2-[(4-Chlorobenzyl)sulfanyl]-1,3-benzothiazol-6-yl}-2-(4-morpholinylcarbonyl)benzamide Benzamide, N-[2-[[(4-chlorophenyl)methyl]thio]-6-benzothiazolyl]-2-(4-morpholinylcarbonyl)-

Description	CID1231538, a benzothiazole analogue, is a potent GPR35 antagonist (IC50=0.55 μM). GPR35 is a G protein-coupled receptor (GPCR)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	GPR35 has gained special consideration as a result of its association with many diseases including type-2 diabetes, nociceptive pain, inflammation, mild mental retardation syndrome, metabolic disorders, and gastric cancer[1].
References	[1]. Abdalhameed MM, et al. Structure-activity relationships of benzothiazole GPR35 antagonists. Bioorg Med Chem Lett. 2017;27(3):612-615.