Propylparaben sodium

Names

[ Name ]:
Propylparaben sodium

[Synonym ]:
Propylparaben sodium
SODIUM PROPYLPARABEN
EINECS 252-488-1
4-Hydroxybenzoic acid, propyl ester, sodium salt
Natrium propyl 4-hydroxybenzoat
Propylparaben sodium salt
Sodium propyl 4-hydroxybenzoate
MFCD00016477
sodium 4-propoxycarbonylphenoxide
propyl p-hydroxybenzoate sodium salt
Propylis parahydroxybenzoas natricum
Propylparaben, sodium salt
UNII-625NNB0G9N
Sodium 4-(propoxycarbonyl)phenolate
Propyl 4-hydroxybenzoate sodium salt
Benzoic acid, 4-hydroxy-, propyl ester, sodium salt (1:1)
Caswell No. 714A
4-hydroxybenzoic acid propyl ester sodium salt
Parasept
sodium propyl parahydroxybenzoate

Biological Activity

[Description]:

Propylparaben sodium is an antimicrobial agent, preservative, flavouring agent[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. S Oishi, et al. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 2002 Dec;40(12):1807-13.

Chemical & Physical Properties

[ Boiling Point ]:
294.3ºC at 760 mmHg

[ Melting Point ]:
96-97ºC

[ Molecular Formula ]:
C₁₀H₁₁NaO₃

[ Molecular Weight ]:
202.182

[ Flash Point ]:
124.6ºC

[ Exact Mass ]:
202.060593

[ PSA ]:
49.36000

[ LogP ]:
2.39720

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2850000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, propyl ester, sodium deriv.

CAS REGISTRY NUMBER :: 35285-69-9

LAST UPDATED :: 199107

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H11-O3.Na

MOLECULAR WEIGHT :: 202.20

WISWESSER LINE NOTATION :: OR DVO3 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 490 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRSTAT Drug Standards. (Washington, DC) V.19-28, 1951-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 20,89,1952

Safety Information

[ Hazard Codes ]:
C

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
2

[ RTECS ]:
DH2850000

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909500000

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%