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Bicyclopyrone

Names

[ CAS No. ]:
352010-68-5

[ Name ]:
Bicyclopyrone

[Synonym ]:
4-Hydroxy-3-[2-(2-methoxyethoxymethyl)-6-trifluoromethylpyridine-3-carbonyl]-bicyclo[3.2.1]oct-3-en-2-one
4-hydroxy-3-{[2-(2-methoxy-ethoxy)methyl-6-(trifluoromethyl)-3-pyridinyl]carbonyl}bicyclo[3.2.1]oct-3-en-2-one
rac-(1R,5R)-4-hydroxy-3-{2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)pyridine-3-carbonyl}bicyclo[3.2.1]oct-3-en-2-one
4-hydroxy-3-{2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)-3-pyridylcarbonyl}bicyclo[3.2.1]oct-3-en-2-one
4-Hydroxy-3-[1]naphthylmethyl-benzoesaeure
4-hydroxy-3-[1]naphthylmethyl-benzoic acid
4-hydroxy-3-[[2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)-3-pyridinyl]carbonyl]bicyclo[3.2.1]oct-3-en-2-one
4-hydroxy-3-(2-methoxyethoxymethyl-6-trifluoromethyl-pyridin-3-yl-carbonyl)-bicyclo[3.2.1]oct-3-en-2-one
4-Hydroxy-3-({2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)-3-p yridinyl}carbonyl)bicyclo[3.2.1]oct-3-en-2-one
Benzoic acid,4-hydroxy-3-(1-naphthalenylmethyl)

Biological Activity

[Description]:

Bicyclopyrone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (Hpd)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

4-hydroxyphenylpyruvate dioxygenase catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate is the last step in the melanin biosynthesis pathway[1].

[References]

[1]. María Elisa Pavan, et al. Glycerol inhibition of melanin biosynthesis in the environmental Aeromonas salmonicida 34mel T. Appl Microbiol Biotechnol. 2019 Feb;103(4):1865-1876.

Chemical & Physical Properties

[ Density]:
1.387g/cm3

[ Boiling Point ]:
489.521ºC at 760 mmHg

[ Molecular Formula ]:
C19H20F3NO5

[ Molecular Weight ]:
399.36

[ Flash Point ]:
249.853ºC

[ Exact Mass ]:
399.12900

[ PSA ]:
85.72000

[ LogP ]:
3.25720

[ Index of Refraction ]:
1.547

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Related Compounds

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