CBA

Names

[ Name ]:
CBA

[Synonym ]:
Benzoic acid, 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]-
4-Chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid

Biological Activity

[Description]:

TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx); selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6.

[References]

References 1. Ozhathil LC, et al. Br J Pharmacol. 2018 Jun;175(12):2504-2519. View Related Products by Target TRP Channel

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
576.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₁Cl₂NO₄

[ Molecular Weight ]:
340.158

[ Flash Point ]:
302.4±30.1 °C

[ Exact Mass ]:
339.006500

[ LogP ]:
4.95

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.656

Related Compounds

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