Nemorosone

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

apoptosis[1]

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1]. Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1]. Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1]. Cell Proliferation Assay[1] Cell Line: HT-29 and LoVo cells Concentration: 0-50 μM Incubation Time: 24-72 h Result: Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively. Cell Cycle Analysis[1] Cell Line: HT-29 and LoVo cells Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo Incubation Time: 24, 48 hours Result: Increased the percentage of G0/G1 phase cells. Apoptosis Analysis[1] Cell Line: HT-29 and LoVo cells Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo Incubation Time: 24, 48 hours Result: Induced apoptosis in both cell lines.

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2]. Animal Model: Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2] Dosage: 50 mg/kg Administration: Daily i.p. injections for 28 days Result: Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

[1]. Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5):1827. Published 2020 Mar 6.

[2]. Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8(9):e74555. Published 2013 Sep 5.