β-Estradiol-6-one 6-(O-carboxymethyloxime)

Names

[ Name ]:
β-Estradiol-6-one 6-(O-carboxymethyloxime)

[Synonym ]:
((((17β)-3,17-Dihydroxyestra-1,3,5(10)-trien-6-ylidene)amino)oxy)acetic acid
Beta-Estradiol-6-one 6-(O-carboxymethyloxime)
Acetic acid, 2-[[[(6E,17β)-3,17-dihydroxyestra-1(10),2,4-trien-6-ylidene]amino]oxy]-
17β-estradiol 6-O-(carboxymethyl)oxime
1,3,5[10]-ESTRATRIENE-3,17-DIOL-6-ONE 6-[O-CARBOXYMETHYL]OXIME
17beta-estradiol 6-O-(carboxymethyl)oxime
β-Estradiol-6-one 6-(O-carboxymethyloxime)
SS-ESTRADIOL-6-ONE 6-(O-CARBOXYMETHYLOXIME)
6-keto-1,3,5(10)estratriene-3,17β-diol 6-carboxymethyloxime
({(E)-[(6E,17β)-3,17-Dihydroxyestra-1(10),2,4-trien-6-ylidene]amino}oxy)acetic acid

Biological Activity

[Description]:

β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
572.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₅NO₅

[ Molecular Weight ]:
359.416

[ Flash Point ]:
300.1±32.9 °C

[ Exact Mass ]:
359.173279

[ PSA ]:
99.35000

[ LogP ]:
2.31

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.680

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

A convenient homogeneous enzyme immunoassay for estradiol detection.

Biotechnol. Appl. Biochem. 58(1) , 75-82, (2011)

A convenient homogeneous enzyme immunoassay for estradiol is described. Unlike heterogeneous immunoassays, which require time-consuming separation steps or expensive automated systems, homogeneous imm...

Histochemical estrogen receptor assay.

Am. J. Clin. Pathol. 76(3) , 365, (1981)

Estrogen receptors in human breast cancer. II. Correlation between the histochemical method and biochemical assay.

Virchows Arch.,. B, Cell Pathol. 40(1) , 27-37, (1982)

The present study defines criteria for determining the presence of estrogen-receptors in human breast carcinomas demonstrated by a histochemical assay using 17 beta-estradiol-carboxy-methyl-oxim-bovin...

Related Compounds

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