5'-[[(3S)-3-AMINO-3-CARBOXYPROPYL]METHYLSULFONIO]-5'-DEOXY-ADENOSINE IODIDE

Names

[ Name ]:
5'-[[(3S)-3-AMINO-3-CARBOXYPROPYL]METHYLSULFONIO]-5'-DEOXY-ADENOSINE IODIDE

[Synonym ]:
EINECS 222-486-5
SAM iodide salt
S-(5'-ADENOSYL)-L-METHIONINE IODIDE
S-ADENOSYL METHIONINE IODIDE SALT
adomet
MFCD00043192
S-(5'-deoxy-5'-adenosyl)methionine iodide
S-adenosylmethionine
SAM-E IODIDE SALT
AdoMet,SAM
S-adenosyl-L-methionine iodide
S-ADENOSYLMETHIONINE IODIDE
S-adenosylmethione

Biological Activity

[Description]:

S-(5'-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) is an important methyl donor that is found in all living organisms[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

By donating the methyl group, sues that involves perchloric acid extraction has beenSAM is converted into S-adenosyl-L-homocysteine reported by She et al. Separation of SAM and (SAH)[1].

[References]

[1]. W Wang, et al. Reversed-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in mouse liver and the effect of methionine on their concentrations. J Chromatogr B Biomed Sci Appl. 2001 Oct 5;762(1):59-65.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₃IN₆O₅S

[ Molecular Weight ]:
526.35000

[ Exact Mass ]:
526.05000

[ PSA ]:
207.93000

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 100 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

In vitro and in vivo biotransformation of WMS-1410, a potent GluN2B selective NMDA receptor antagonist.

J. Pharm. Biomed. Anal. 94 , 36-44, (2014)

Structural modification of the GluN2B selective NMDA receptor antagonist ifenprodil led to the 3-benzazepine WMS-1410 with similar GluN2B affinity but higher receptor selectivity. Herein the in vitro ...

Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.

J. Biol. Chem. 287 , 1426-1434, (2012)

In the malarial parasite Plasmodium falciparum, a multifunctional phosphoethanolamine methyltransferase (PfPMT) catalyzes the methylation of phosphoethanolamine (pEA) to phosphocholine for membrane bi...

DNA methyltransferases: mechanistic models derived from kinetic analysis.

Crit. Rev. Biochem. Mol. Biol. 47(2) , 97-193, (2012)

The sequence-specific transfer of methyl groups from donor S-adenosyl-L-methionine (AdoMet) to certain positions of DNA-adenine or -cytosine residues by DNA methyltransferases (MTases) is a major form...

Related Compounds

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