Fedovapagon

Names

[ Name ]:
Fedovapagon

[Synonym ]:
1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)benzylcarbamoyl)-L-proline-N,N-dimethylamide
UNII-VX2GBO4I0V
Fedovapagon
Fedovapagon [INN]
(2S)-N2,N2-dimethyl-N1-((2-Methyl-4-(2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)phenyl)methyl)pyrrolidine-1,2-dicarboxamide
(2S)-N(sup 2),N(sup 2)-Dimethyl-N(sup 1)-((2-methyl-4-(2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)phenyl)methyl)pyrrolidine-1,2-dicarboxamide

Biological Activity

[Description]:

Fedovapagon is a selective vasopressin V2 receptor (V2R) agonist with an EC50 of 24 nM, which is being developed for the treatment of nocturia[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

EC50：24 nM (V2R)[1]

[References]

[1]. Yea CM, et al. New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem. 2008 Dec 25;51(24):8124-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₄N₄O₃

[ Molecular Weight ]:
462.58400

[ Exact Mass ]:
462.26300

[ PSA ]:
76.45000

[ LogP ]:
3.94760

Related Compounds

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