Ticarcillin

Names

[ Name ]:
Ticarcillin

[Synonym ]:
(2S,5R,6R)-6-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Temocillin Disodium
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-,[2S-[2a,5a,6b(S*)]]
6-[D(-)-a-Carboxy-3-thienylacetamido]penicillanic Acid
EINECS 252-213-5
(2S,5R,6R)-6-{[(2R)-2-Carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Ticarcillin
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-yl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-[D-(-)-a-Carboxy-3-thienylacetamido]penicillanic acid
a-Carboxy-3-thienylmethylpenicillin
N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-3-thiophenemalonamic Acid
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
TRIARCILLIN
MFCD00864998
Ticcarcillin acid

Biological Activity

[Description]:

Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities[1]. Cell Viability Assay[2] Cell Line: Ps. aeruginosa Concentration: 10 mg/L Incubation Time: 18 hours Result: Showed the MIC for Ticarcillin against strain between 6.3-12.5 mg/L.

[In Vivo]

Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect[2]. Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment[2]. Animal Model: Swiss type male mice injected with Ps. aeruginosa[2] Dosage: 50, 100, 200 mg/kg Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once Result: Increased effect significantly (0.001 < P < 0.0025) with increasing dose. Animal Model: Swiss type male mice injected with Ps. aeruginosa[2] Dosage: 50, 100, 200 mg/kg Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once Result: Dose (mg/kg) AUCa (mg/kg) Kelb (h-1) T1/2 (min) Ticarcillin 50 8.76 (0.72) 1.57 (0.18) 26 100 26.14 (0.60) 1.53 (0.11) 27 200 54.56 (2.90) 1.47 (0.12) 28

[References]

[1]. Cecile Formosa, et al. Nanoscale effects of antibiotics on P. aeruginosa. Nanomedicine. 2012 Jan;8(1):12-6.

[2]. G B van der Voet, et al. Comparison of the antibacterial activity of azlocillin and ticarcillin in vitro and in irradiated neutropenic mice. J Antimicrob Chemother. 1985 Nov;16(5):605-13.

[3]. Oriel Spierer, et al. Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates. Br J Ophthalmol. 2018 May;102(5):708-712.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
768.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₆N₂O₆S₂

[ Molecular Weight ]:
384.427

[ Flash Point ]:
418.4±32.9 °C

[ Exact Mass ]:
384.044983

[ PSA ]:
177.55000

[ LogP ]:
0.69

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.694

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
22-36/37-45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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