2-(benzo[d]thiazol-2-yl)-2-(2-chloropyrimidin-4-yl)acetonitrile

Names

[ Name ]:
2-(benzo[d]thiazol-2-yl)-2-(2-chloropyrimidin-4-yl)acetonitrile

[Synonym ]:
Benzothiazole,2-[(phenylmethyl)sulfonyl]
2-phenylmethanesulfonyl-benzothiazole
1,3-benzothiazol-2-yl(2-chloro-4-pyrimidinyl)-acetonitrile
2-Phenylmethansulfonyl-benzothiazol
1,3-benzothiazol-2-yl benzyl sulfone
benzothiazol-2-yl-(2-chloro-pyrimidin-4-yl)-acetonitrile
2-<(phenylmethyl)sulfonyl>benzothiazole
2-(benzylsulfonyl)benzothiazole
benzothiazol-2-benzyl sulfone
2-(benzylsulfonyl)benzo[d]thiazole

Biological Activity

[Description]:

JNK-IN-13 (compound 1) is a potent and selective JNK inhibitor with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK2:500 nM (IC50)

JNK3:290 nM (IC50)

[References]

[1]. Serge Halazy, et al. Benzazole derivatives and their use as JNK modulators. EP1110957A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₇ClN₄S

[ Molecular Weight ]:
286.74

[ Exact Mass ]:
286.00800

[ PSA ]:
90.70000

[ LogP ]:
3.39518

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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