4-Hydroxyacetophenone oxime

Names

[ Name ]:
4-Hydroxyacetophenone oxime

[Synonym ]:
p-hydroxyacetophenone oxime
4-hydroxyphenyl methyl ketone oxime
methyl p-hydroxyphenyl ketone oxime

Biological Activity

[Description]:

4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic drug[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.

[2]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9.

Chemical & Physical Properties

[ Density]:
1.246g/cm3

[ Boiling Point ]:
294.8ºC at 760mmHg

[ Melting Point ]:
143 °C

[ Molecular Formula ]:
C₈H₉NO₂

[ Molecular Weight ]:
151.16300

[ Flash Point ]:
132.1ºC

[ Exact Mass ]:
151.06300

[ PSA ]:
52.82000

[ LogP ]:
1.59040

[ Index of Refraction ]:
1.591

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

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