Collinin

Names

[ Name ]:
Collinin

[Synonym ]:
7-(3,7-dimethyl-octa-2,6-dienyloxy)-8-methoxy-chromen-2-one
7-(3,4-dichloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]diazepino[2,1-a]isoindol-7-ol
2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanol
1-Piperazineethanol,4-(3-(trifluoromethyl)phenyl)
2-(4-(3-(Trifluoromethyl)phenyl)-1-piperazinyl) ethanol
m-Trifluoro-methyl-4-phenyl-1-piperazinoethanol

Biological Activity

[Description]:

Collinin is a anti-tubercular agent, it can be isolated from leaves of Z. schinifolium. Collinin has an excellent anti-tuberculosis effect against multidrug-resistant (MDR), extensively drug-resistant (XDR) strains[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Collinin在培养基中显著抑制 MDR 和 XDR 结核分枝杆菌的生长，50% 最低抑制浓度 (MIC50s) 为 3.13-6.25 µg/mL[1]。 Collinin抑制 Raw264.7 和 A549 细胞内药敏和耐药结核的生长，MIC50 为6.25-12.50 µg/mL[1]。

[References]

[1]. Kim S, et al. In vitro activity of collinin isolated from the leaves of Zanthoxylum schinifolium against multidrug- and extensively drug-resistant Mycobacterium tuberculosis. Phytomedicine. 2018 Jul 15;46:104-110.

Chemical & Physical Properties

[ Density]:
1.092g/cm3

[ Boiling Point ]:
487.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₄O₄

[ Molecular Weight ]:
328.40200

[ Flash Point ]:
213.2ºC

[ Exact Mass ]:
328.16700

[ PSA ]:
48.67000

[ LogP ]:
4.87310

[ Index of Refraction ]:
1.542

Related Compounds

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