C18 Phytoceramide (t18:0/18:0)

Names

[ Name ]:
C18 Phytoceramide (t18:0/18:0)

[Synonym ]:
N-[(3S)-1,3,4-Trihydroxy-2-octadecanyl]octadecanamide

Biological Activity

[Description]:

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₇₃NO₄

[ Molecular Weight ]:
583.96900

[ Exact Mass ]:
583.55400

[ PSA ]:
93.28000

[ LogP ]:
10.37830

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Calorimetric and spectroscopic investigations of phytosphingosine ceramide membrane organisation. Garidel P

Phys. Chem. Chem. Phys. 4(10) , 1934-1942, (2002)