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Sugammadex

Names

[ CAS No. ]:
343306-71-8

[ Name ]:
Sugammadex

[Synonym ]:
3,3',3'',3''',3'''',3''''',3'''''',3'''''''-{[(1S,3S,5S,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31S,33S,35S,36S,38S,40S,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56 ;R)-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-Hexadecahydroxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.2.2.2.2.2.2.2]h exapentacontane-5,10,15,20,25,30,35,40-octay
cyclooctakis-(1&;rarr;4)-[6-S-(2-carboxyethyl)-6-thio-α-D-glucopyranosyl]
unii-361lpm2t56
Sugammadex
UNII361LPM2T56

Biological Activity

[Description]:

Sugammadex is a synthetic γ-cyclodextrin derivative, and acts as a reversal agent for neuromuscular block. Sugammadex shows nephroprotective effect in ischemia-reperfusion injury[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

Sugammadex (100 mg/kg, IV, once) has a nephroprotective effect when given at the beginning of reperfusion after one hour of ischemic condition on rats[2].

[References]

[1]. de Boer HD, et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth. 2006 Apr;96(4):473-9. Epub 2006 Feb 7.

[2]. Tercan M, Yılmaz İnal F, Seneldir H, Kocoglu H. Nephroprotective Efficacy of Sugammadex in Ischemia-Reperfusion Injury: An Experimental Study in a Rat Model. Cureus. 2021 Jun 17;13(6):e15726.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C72H104Na8O48S8

[ Molecular Weight ]:
2002.151

[ Exact Mass ]:
2000.408813

[ PSA ]:
994.80000

[ LogP ]:
-1.25

[ Index of Refraction ]:
1.610

Related Compounds