D-KLVFFA

Names

[ Name ]:
D-KLVFFA

[Synonym ]:
D-Lys-D-Leu-D-Val-D-Phe-D-Phe-D-Ala trifluoroacetate salt
D-KLVFFA

Biological Activity

[Description]:

D-KLVFFA is the inhibitor of Amyloid-β assembly, with the IC50 of 2.6 μM, that can be used in Alzheimer's disease study[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Robert J Chalifour, et al. Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide. J Biol Chem. 2003 Sep 12;278(37):34874-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₅₈F₃N₇O₉

[ Molecular Weight ]:
837.92500

[ Exact Mass ]:
837.42500

[ PSA ]:
289.59000

[ LogP ]:
7.39410

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide.

J. Biol. Chem. 278 , 34874-34881, (2003)

Residues 16-20 of the beta-amyloid peptide (A beta) function as a self-recognition element during A beta assembly into fibers. Peptides containing this motif retain the ability to interact with A beta...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.