GID4 Ligand 3

Names

[ Name ]:
GID4 Ligand 3

[Synonym ]:
3-[(5-Methyl-4,5-dihydro-1,3-thiazol-2-yl)amino]phenol
Phenol, 3-[(4,5-dihydro-5-methyl-2-thiazolyl)amino]-
MFCD01655227

Biological Activity

[Description]:

GID4 Ligand 3 (compound 16) is a binder of GID4 with an Kd value of 110 μM in vitro and an IC50 value of 148.5 μM. GID4 Ligand 3 can be used for the research related to cereblon and Von Hippel-Lindau[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 148.5 μM (GID4)[1]

[In Vitro]

GID4 Ligand 3 (0-1000 μM; 30 min) binds with GID4 with a Kd value of 110 μM[1].

[References]

[1]. Chana CK, et al. Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J Med Chem. 2022 Sep 18.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
366.5±44.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂N₂OS

[ Molecular Weight ]:
208.280

[ Flash Point ]:
175.4±28.4 °C

[ Exact Mass ]:
208.067032

[ LogP ]:
1.20

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.663

Related Compounds

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