ACTH (6-24) (human)

Names

[ Name ]:
ACTH (6-24) (human)

Biological Activity

[Description]:

ACTH (6-24) (human) (Adrenocorticotropic hormone (6-24)) is an ACTH fragment. ACTH (6-24) (human) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) (Kd:13.4 and 3.4 nM). ACTH (6-24) (human) inhibits corticosterone production and cAMP accumulation induced by hPTH 1-34[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Rafferty B, et al. Corticosteroidogenesis and adenosine 3', 5'- monophosphate production by the amino-terminal (1-34) fragment of human parathyroid hormone in rat adrenocortical cells. Endocrinology. 1983 Sep;113(3):1036-42.

[2]. Bristow AF, et al. Effects of ACTH (corticotropin) analogues on steroidogenesis and cyclic AMP in rat adrenocortical cells. Evidence for two different steroidogenically responsive receptors. Biochem J. 1980 Feb 15;186(2):599-603.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁₁H₁₇₅N₃₅O₂₁

[ Molecular Weight ]:
2335.83

Related Compounds

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