BIBF0775

Names

[ Name ]:
BIBF0775

Biological Activity

[Description]:

BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[Target]

IC50: 34 nM (Alk5)[1]

[References]

[1]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI). J Med Chem. 2010 Oct 28;53(20):7287-95.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₄N₄O₂

[ Molecular Weight ]:
494.63

[ Storage condition ]:
2-8℃

Related Compounds

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