334951-90-5

334951-90-5 structure

Name: BIBF0775
Chemical Name: BIBF0775
CAS Number: 334951-90-5
Molecular Formula: C₃₁H₃₄N₄O₂
Molecular Weight: 494.63
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2019-03-30 19:48:34
Modify Date: 2024-01-08 20:15:00
BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM.

Name	BIBF0775

Description	BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Target	IC50: 34 nM (Alk5)[1]
References	[1]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI). J Med Chem. 2010 Oct 28;53(20):7287-95.