HexylHIBO

Names

[ Name ]:
HexylHIBO

[Synonym ]:
hexylhibo

Biological Activity

[Description]:

HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vitro]

Thus ambient levels of glutamate tonically activate mGluRs and regulate cortical excitability[1].

[References]

[1]. Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44(7):1051-1059.

[2]. Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89(3):1308-1316.

Chemical & Physical Properties

[ Density]:
1.176 g/cm3

[ Molecular Formula ]:
C₁₂H₂₀N₂O₄

[ Molecular Weight ]:
256.29800

[ Exact Mass ]:
256.14200

[ PSA ]:
109.32000

[ LogP ]:
1.74540

Related Compounds

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