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2'-O-MOE-N6-Bz-rA

Names

[ CAS No. ]:
333335-93-6

[ Name ]:
2'-O-MOE-N6-Bz-rA

[Synonym ]:
Adenosine,N-benzoyl-2'-O-(2-methoxyethyl)
2'-O-MOE-N6-Bz-rA

Biological Activity

[Description]:

N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23N5O6

[ Molecular Weight ]:
429.43

[ Exact Mass ]:
429.16500

[ PSA ]:
144.34000

[ LogP ]:
0.74480

Related Compounds