5-Fluoro-2-methylbenzoic acid

Names

[ Name ]:
5-Fluoro-2-methylbenzoic acid

[Synonym ]:
3-Fluoro-6-methylbenzoic acid
5-Fluoro-2-methylbenzoic acid
QVR CF F1
5-Fluoro-2-methyl-benzoic acid
5-Fluor-2-methyl-benzoesaeure
Benzoic acid,5-fluoro-2-methyl
MFCD00042294
Benzoic acid, 5-fluoro-2-methyl-
2-methyl-5-fluorobenzoic acid
5-Fluoro-o-toluic acid
5-Fluoro-2-methyl benzoicacid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
262.1±20.0 °C at 760 mmHg

[ Melting Point ]:
130-132 °C(lit.)

[ Molecular Formula ]:
C₈H₇FO₂

[ Molecular Weight ]:
154.138

[ Flash Point ]:
112.3±21.8 °C

[ Exact Mass ]:
154.043015

[ PSA ]:
37.30000

[ LogP ]:
2.62

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.533

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor. Gillmore AT, et al.

Org. Process Res. Dev. 16(12) , 2063-72, (1999)

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.

Bioorg. Med. Chem. 19 , 4935, (2011)

HIV-1 integrase (IN) is a validated therapeutic target for antiviral drug design. However, the emergence of viral strains resistant to clinically studied IN inhibitors demands the discovery of novel i...

Structure-activity relationship of HIV-1 protease inhibitors containing alpha-hydroxy-beta-amino acids. Detailed study of P1 site.

Bioorg. Med. Chem. 7(9) , 2063-72, (1999)

The structure-activity relationship of HIV-1 protease (HIV-1 PR) inhibitors containing alpha-hydroxy-beta-amino acids is discussed. We demonstrated that substituent groups on the P1 aromatic rings of ...