S.pombe lumazine synthase-IN-1

Names

[ Name ]:
S.pombe lumazine synthase-IN-1

Biological Activity

[Description]:

S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Ki: 243 μM (Schizosaccharomyces pombe lumazine synthase); 9.6 μM (Mycobacterium tuberculosis lumazine synthase)[1]

[In Vitro]

S.pombe lumazine synthase-IN-1 (Compound 21) is a class II compound with OCH3 groups displays slightly better potencies than its counterparts with OH groups[1].

[References]

[1]. Arindam Talukdar, et al. Discovery and Development of a Small Molecule Library With Lumazine Synthase Inhibitory Activity. J Org Chem. 2009 Aug 7;74(15):5123-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₃N₃O₆

[ Molecular Weight ]:
319.27

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.