CFM-4

Names

[ Name ]:
CFM-4

[Synonym ]:
CFM-4
L-703,664 succinate

Biological Activity

[Description]:

CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₆ClN₃OS

[ Molecular Weight ]:
405.90

[ Exact Mass ]:
405.07000

[ PSA ]:
70.00000

[ LogP ]:
4.56720

Related Compounds

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