PHF6 trifluoroacetate salt

Names

[ Name ]:
PHF6 trifluoroacetate salt

[Synonym ]:
L-Lysine,L-valyl-L-glutaminyl-L-isoleucyl-L-valyl-L-tyrosyl
PHF6 trifluoroacetate salt

Biological Activity

[Description]:

PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Aggregated tau-PHF6 (VQIVYK) potentiates NLRP3 inflammasome expression and autophagy in human microglial cells[1].

[References]

[1]. Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10(7):1652.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₆₀N₈O₉

[ Molecular Weight ]:
748.91

[ Exact Mass ]:
748.44800

[ PSA ]:
316.60000

[ LogP ]:
6.27500

Related Compounds

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